Crystallography and Molecular Imaging using X-ray Lasers

Thomas Ashley White


A very successful application of X-ray free-electron lasers has been made in structural biology. Acquiring diffraction data using X-ray pulses with durations of a few tens of femtoseconds allows the conventional processes of radiation damage to be sidestepped, breaking limits that previously applied, while at the same time permitting experiments to probe chemical dynamics on short timescales. This contribution gives an introduction to applications of free-electron lasers in biochemistry, including potential future applications to single-molecule diffraction.


Crystallography; biochemistry; free-electron laser.

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